Cancer Advances
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Featured Episode
Pre-Taxane Lutetium in Prostate Cancer: Changing the Treatment Algorithm
Is there a role for earlier integration of lutetium PSMA therapy in mCRPC management? Emerging evidence supports its use in the pre-taxane setting, prompting a shift in sequencing decisions. This episode outlines patient selection, PSMA imaging requirements and how to balance disease aggressiveness, tolerability and real-world considerations when choosing between lutetium and chemotherapy.
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May 21, 2026
Using Dynamic Models to Inform Treatment and Prognosis in AML
How can we better predict progression and outcomes in a disease where treatment decisions must be made in days, sometimes hours? In this episode of Cancer Advances, Moaath Mustafa Ali, MD, MPH, discusses emerging longitudinal and evolutionary modeling approaches that integrate clinical, genomic and treatment data over time to improve risk stratification in acute myeloid leukemia. Learn how these models may support earlier, more informed decisions around therapy selection, relapse risk and long-term management.
Play NowMay 20, 2026
Rethinking "More Is Better": Deescalating Cancer Care
As cancer care becomes increasingly personalized, treatment deescalation is emerging as a key strategy to balance efficacy with quality of life. In this episode of Cancer Advances, Jame Abraham, MD, Enterprise Chair of Hematology and Medical Oncology at Cleveland Clinic, discusses how clinicians are rethinking dose intensity, duration and therapeutic selection across disease settings. Learn how evolving evidence, patient preferences and emerging technologies like AI are shaping treatment decisions and redefining standards of care.
Play NowMay 14, 2026
Preserving Fertility During Pelvic Radiation: A Multidisciplinary Surgical Approach
Young patients requiring pelvic radiation face limited fertility preservation options. In this episode of Cancer Advances, Robert DeBernardo, MD, and Johanna Kelley, MD, both gynecologic oncologists at Cleveland Clinic, discuss uterine transposition—a novel surgical approach that protects both ovarian function and the uterus—using a real world rectal cancer case. Learn which patients may benefit, how the multidisciplinary model works and what this technique could mean for counseling, referrals and long term reproductive outcomes.
Play NowMay 7, 2026
Optimizing Treatment Decisions in Muscle-Invasive Bladder Cancer
Shilpa Gupta, MD, Genitourinary Medical Oncologist, joins the Cancer Advances podcast to explore how perioperative immunotherapy and ctDNA are redefining management of muscle-invasive bladder cancer. She reviews emerging phase III data and explains how it can inform treatment selection, referral timing and adjuvant decision making in clinical practice.
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